Neuronal death Involvement of Rag1 activation

Although the transcription factor, nuclear factor survival, its precise role in cell death within the central nervous system (CNS) remains unknown. previously reported that mice with a homozygous deficiency for NF optic neuropathy. We examined the expression and activation of pro mediate optic neuropathy in p50 known to regulate the recombination of immunoglobulin V(D)J. Experiments with gene engineered mice revealed the involvement of Rag1 expression in the apoptosis of Brn3a retinal ganglion cells (RGCs), and also showed the specific effects of a p50 activation of Rag1 gene transcription. Furthermore, a gene cells clarified the biological significance of Rag1 in NMDA apoptosis. The apoptotic regulating factors, Bax, and cleaved caspase HEK293 cells expressing the external molecule of Rag1, and a human histological examination revealed the expression of Rag1 in RGCs. neuropathy as a pro-apoptotic candida targets in optic neuropathy.